摘要
目的：观察大剂量川芎嗪对肺原性心脏病（肺心病）急性加重期的疗效。方法：将肺心病急性加重期患者１３０例分成３组：Ａ组４０例予西医常规治疗；Ｂ组４０例在西医常规治疗基础上加川芎嗪注射液８０～１２０ｍｇ／ｄ静滴；Ｃ组５０例常规治疗基础上加川芎嗪注射液８００～１２００ｍｇ／ｄ静滴。结果：Ａ、Ｂ、Ｃ３组显效率分别为４５％、５０％和８０％，总有效率分别为７５％、８０％和９４％。Ａ、Ｂ组与Ｃ组总有效率比较均有显著性差异（Ｐ均＜０．０５）。结论：大剂量川芎嗪治疗肺心病疗效好且安全，无明显毒副作用。
Objective:To observe the therapeutic effect of tetramethylpyrazine in large dosage on acute exacerbation with cor pulmonale.Methods:One hundred and thirty cases of acute exacerbation with cor pulmonale were divided into 3 groups.Group A(40 cases) was treated with conventional therapy;group B (40 cases) was treated with tetramethylpyrazine injection 80￣120 mg/d intravenous drip besides conventional therapy;group C (50 cases) was treated with tetramethylpyrazine injection 800￣1 200 mg/d intravenous drip on the basis of conventional therapy.Results:The obvious effective rates were 45%,50% and 80% in group A,B and C respectively.The total effective rates were 75%,80% and 94% in group A,B and C respectively,and it was obvious difference between group A,B and group C (all P<005).Conclusions:There is safe,reliableness and no sideeffect of tetramethylpyrazine in large dosage for treating cor pulmonale.
