芦氟沙星与洛美沙星随机对照治疗急性细菌性感染

Randomizedcontrolled study on rufloxacin in comparison with lomefloxacin in the treatment of acute bacterial infections

通过芦氟沙星与洛美沙星随机对照治疗急性细菌性感染，评价前者的安全性、有效性。芦氟沙星治疗呼吸道、泌尿道及皮肤软组织感染４６例，洛美沙星治疗相应系统感染４９例。结果显示芦氟沙星组与洛美沙星组不同病种的临床痊愈率为７６．０９％与６７．３５％，有效率为９３．４８％与９０．００％；两组的细菌清除率为９２．６８％与９７．６２％；不同细菌所致感染的临床痊愈率为７８．０５％与７８．５７％，有效率为９２．６８％与９５．２４％；所分离细菌的纸片敏试高敏率为８３．１３％与９１．５７％；不良反应发生率分别为１３．０４％与１２．２４％，两组各对应指标经统计学处理，Ｐ＞０．０５，差异无显著性。表明芦氟沙星作为一种长效氟喹诺酮类抗生素，使用方便，不良反应少，可有效治疗轻中度呼吸系统、泌尿系统及皮肤软组织感染。

? The safety and efficacy of domestic rufloxacin were evaluated by randomized controlled study in comparison with lomefloxacin in the treatment of acute bacterial infections. Fourtysix patients with respiratory, urinary tract and skinsoft tissue infections treated with rufloxacin. Fourtynine patients treated with lomefloxacin. Results showed the total efficacy rates of rufloxacin and lomefloxacin were 93.48% and 90.00%, bacterial eradication rate were 92.68% and 97.62%, the efficacy rates of patients based on bacterial species were 92.68% and 95.64%, the high sensitive rates of bacteria were 83.13% and 91.57% and adverse reaction rates were 13.04% and 12.24%. The relative data between trial group and control group had no significant statistic difference (P>0.05). The results suggested that rufloxacin as a longacting floquinolone antibiotics, with mild adverse reaction, are well suited to be used in treatment of acute bacterial infection.