缝隙连接蛋白及其与心房颤动关系研究进展

Progression of Research in Gap Connexins and Its Relationship with Atrial Fibrillation

心房颤动的发生和维持与缝隙连接蛋白密切相关。近年来发现心房颤动的伴随症状如心房纤维化、心房扩大、炎症以及遗传因素均可独立于心房颤动之外使缝隙连接蛋白发生改变,从而促进心房颤动的发生与维持。对心房颤动伴随症状的治疗有望成为心房颤动治疗的新靶点。

The incidence and maintenance of atrial fibrillation were closely tied with connexins. In recent years, researchers found that symptoms accompanying atrial fibrillation such as atrial fibrosis, atrial dilation, inflammation and genetic factors can make connexins change independently of atrial fibrillation, leading to the occurrence and maintenance of atrial fibrillation. The treatment of symptoms accompanying atrial fibrillation is expected to hecome a new target for the treatment of atrial fibrillation.