3533例男性不育症患者精液标本的支原体检测与耐药性分析

Study on semen detection of 3533 infertile men and drug resistance of mycoplasma to antibiotics

目的了解我院近三年来男性不育症患者精液标本衣原体、支原体的感染情况和支原体对抗生素的耐药性，为临床治疗用药提供依据。方法对2004～2006年间来我院生殖中心就诊的不同病因的3533例男性不育症患者的精液标本进行支原体和衣原体的检测，同时对支原体检测阳性的标本进行了菌落计数和抗生素敏感性检测，分析其耐药情况。结果2004、2005、2006年的413、1303、1817份男性不育症患者的精液标本中分别有18、124、66份精液标本衣原体金标试验阳性，分别有119、304、408份精液标本检到支原体，检到的支原体以解脲支原体为主，解脲支原体对氧氟沙星耐药率最高、交沙霉素耐药率最低。结论我院近三年男性不育症患者的精液标本中支原体和衣原体是主要的病原，检测支原体的耐药性对合理用药、指导临床治疗和提高不育症患者的生育率具有重要意义。

Objective ： To investigate the distribution of mycoplasma and Chlamydia trachomatis isolated from the semen of infertile men in our hospital last three years and the antimicrobial resistance of mycoplasma so as to provide clinicians with grounds for choosing antibiotic agents. Methods： Mycoplasma and Chlamydia trachomatis in semen, s samples from 3533 infertile men with variable reasons 2004 -2006 were detected. At the same time antimicrobial resistance of mycoplasma were statistically analyzed. Results： Respectively 18, 124 and 66 samples were detected Chlamydia trachomatis last three years; 119, 304 and 408 samples were detected mycoplasma and ureaplasma urealyticum was the most. For the ureaplasma urealyticum , it was the highest against of loxacin , and the lowest against josamycin. Conclusions ： Mycoplasma and Chlamydia trachomatis are the main pathogens about semen of infertile men in our hospital last three years. It is important to keep on detecting pathogens about semen of infertile men and their sensitivity to antibiotics and using them properly so as to increase their procreation rate.