家族性与散发性精神分裂症对照研究

A controlled study on clinical features of familial and sporadic schizophrenia

为探讨家族性与散发性精神分裂症患者的临床特征差异，对３２例家族性和７５例散发性精神分裂症患者进行了临床对照研究。结果显示：家族性与散发性精神分裂症患者的临床特征相比，在发病年龄、出生季节、病前适应能力、病程、阴性症状及意志缺乏，以及即期疗效等方面均有显著性差异。提示家族史与精神分裂症的一些临床特征有密切的关系，家族史作为精神分裂症的一个分类原则是适合的。

Objective:To study the differences in the clinical features between familial and sporadic schizophrenia. Method:Thirty two schizophrenic patients with positive family history were compared with seventy five schizophrenic patients with negative family history. Results:There were significant differences on age of onset,season of birth,premorbid adjustment,course of illness,negative symptoms(total SANS score),abuia and short-term treatment response between the patient and controlled groups. Discussion:There is cloes association between family history and clinical features in schizophrenia.Family history might be a useful tool in the classification of schizophrenia.