一种五元杂环β-环糊精固定相的合成及气相色谱性能研究

Synthesis of a Triazole Heterocyclic β-Cyclodextrin Stationary Phase and It's Property in Capillary Gas Chromatography

制备了一种新的含多氮五元杂环类β-环糊精固定相2,6-二-O-甲基-3-O-亚甲基-[1-(1,2,4)-三唑基]-β-环糊精,对其气相色谱分离性能进行了研究。实验结果表明,杂环官能团的引入较大提高了该固定相的柱表面性能和色谱分离能力。不但对二甲苯、硝甲苯等难分离的芳香族位置异构体,而且对醇、胺、酯等多种类型的手性异构体均有很好的分离能力和手性选择能力。

A new heterocyclic β-cyclodextrin（β-CD） derivative, 2, 6-di-O-methyl-3-O-methylene- [ 1-（1, 2, 4）-triazolyl]-β-CD, was synthesized and used as stationary phase in capillary gas chromatography. Results showed that the β-CD derivative possessed a good column coating property and a chromatographic separation ability after introduction of a triazolyl group. The aromatic position isomers, such as xylene and nitrotoluene, were separated well. Moreover, some chiral compounds including alcohol, amine, ester etc. , were also resolved.