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缺血脑组织内皮素含量变化的实验研究 被引量:4

Reginal brain endothelin change in rabbit cerebral ischemia
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摘要 为探讨内皮素含量变化是否为缺血神经元损伤的危险因素及Ca^(2+)拮抗剂氟桂嗪对脑缺血的保护作用,采用放射免疫分析法,我们测定兔大脑中动脉阻断48小时后缺血区脑组织内皮素含量变化及氟桂嗪对其变化的影响。结果显示,缺血48小时后梗塞区脑组织内皮素含量明显升高(P<0.01),为对照组的10倍,而氟桂嗪能明显降低缺血区脑组织水、内皮素含量(P<0.05)。上述结果提示:缺血脑组织内皮素含量升高是导致缺血神经元损伤的重要因素,氟桂嗪对脑缺血有保护作用。 To study wether reginal brain endothelin change would be an important factor for ischemic neuronal damage and whether calcium antagonist would exert protective effects on cerebral ischemia. We measured the reginal brain endothelin level and observed the influence of flunarizine (FNZ) 48 hours after the rabbit middle cerebral artery occlusion (MCAO) by R1A method. The result showed that the endothelin in the ischemic middle cerebral artery territory was 10 times as much as that in the pseudo-occluded controls and FNZ could significantly decrease the ischemic brain endothelin (P< 0. 05) and the ischemic cerebral edama (P<0. 01 ) after MCAO 18 hours. The results suggested that the increased endothelin level of ischemia brain territory was important factor leading to ischemic neuronal injury, and FNZ had protective effects on cerebral ischemia.
出处 《脑与神经疾病杂志》 1998年第1期12-14,共3页 Journal of Brain and Nervous Diseases
关键词 脑缺血 内皮素 氟桂嗪 神经元损伤 cerebral ischemia Endothelin Flunarizine
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  • 1赵卫国,张天锡.兔MCAo型局灶脑缺血模型的建立[J]中国神经精神疾病杂志,1990(03).

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