锌α2糖蛋白与脂代谢和胰岛素抵抗

Zinc-alpha2-glycoprotein,Lipid Mobilization and Insulin Resistance

锌α2糖蛋白存在于人血浆和多种体液中，最近发现也可由脂肪细胞分泌，是一种新的脂肪因子。锌α2糖蛋白对于脂代谢有重要的影响，能促进脂肪分解和利用；同时也与其他细胞因子相互作用。脂代谢障碍和脂肪因子所导致的胰岛素抵抗在肥胖病、代谢综合征、糖尿病等代谢性疾病中有重要作用。因此，锌α2糖蛋白的研究有助于为这些疾病诊疗提供新思路。

Zinc-alpha2-glycoprotein（ZAG）, present in human plasma and is secreted into many body fluids, has recently been classified as a novel adipokine which is produced and secreted by mature adipocyte. ZAG may act locally to influence adipose tissue, increasing lipid mobilization and utilization and interacting with other adipokines, which may induce insulin resisitance （IR）. IR has been demonstrated make a great role in adiposis, metabolic syndrome, diabetes mellitus. The research of ZAG will provide new ideas for the diagnosis and treatment of these metabolic diseases.