摘要
高迁移率族蛋白B1（HMGB1）是一组高度保守的非组织核蛋白，存在于多种真核细胞的细胞核中。生理状态下HMGB1发挥着核结合蛋白的作用。一旦释放进入细胞间隙，则表现出晚期炎性因子作用。新近的研究显示，HMGB1还具有损伤信号园子、细胞及干细胞趋化吸附因子作用。由于晚期糖基化末端产物受体的广泛存在，HMGB1在多种疾病及组织器官损伤、修复过程中发挥重要作用。
High mobility group box 1 pronetein （ HMGB1 ） is a highly conserved, ubiquitous protein present in the nuclei and cytoplasm. Physiological state of HMGB1 plays a role of nuclear binding protein. Once released into the gap, then show the role of late inflammatory factors. Recent studies have shown that HMGB1 also has the role of injury signal factor,cells and stem cell ehemotactic adsorptive factor. As the advanced glycation end-product receptor exist wide, HMGB1 play an important role in variety of diseases, organ damage, repair process.
出处
《医学综述》
2009年第7期963-966,共4页
Medical Recapitulate
基金
山东省自然科学基金(Y2007C115)
