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microRNA let-7与肿瘤

microRNA let-7 and Tumors
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摘要 微小RNA（miRNA）是一类长18～25个核苷酸的非编码小分子RNA，能与靶mRNA的3’UTR碱基配对，通过抑制mRNA的翻译或直接使mRNA降解，在转录后水平使基因沉默。miRNA调节的基因调控机制与肿瘤的发生、发展密切相关。Let-7是目前研究最为广泛的miRNA之一。在多种肿瘤中，let-7表达下调，提示let-7必然与肿瘤存在一些重要的联系。本文就对let-7的生物学特性、作用机制与肿瘤的关系及其在肿瘤治疗方面的潜在作用进行综述。 MicroRNAs（miRNAs） are a class of about 18 - 25 nucleotides （nt） noncoding RNAs. By binding to imperfect complementary sites in the 3 ＇untranslated regions（UTRs） of target mRNA, miRNAs repress the expression of target-gene post transcriptional. Let-7 is one of miRNA which is most widely researched ,which is a hotpoint of cancer research. In many kinds of tumors,the downredulation of let-7 shows it has important relations with tumors. This review focused on let-7 and discussed its generation, functional mechanisms relationship with tumors and its potential role in biological therapy for tumors.
作者 刘治 雷小勇
机构地区 湖南衡阳南华大学药物药理研究所
出处 《医学综述》 2009年第7期1025-1028,共4页 Medical Recapitulate
关键词 LET-7 肿瘤 微小RNA let-7 Cancer miRNA
分类号 R966 [医药卫生—药理学]
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医学综述
2009年 第7期

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