期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Twist基因的研究进展 被引量：7

Progression of Twist Gene
下载PDF
导出
摘要 Twist是一种高度保守的碱性螺旋．环．螺旋转录因子家族重要成员，在动物与人类的胚胎发育中起关键调控作用。在动物胚胎发育过程中，Twist作为转录因子在诱导细胞移动及组织塑形中起主要作用。最近研究表明，Twist在表皮一间叶细胞转换调控中起着关键作用，Twist过表达在肿瘤的发生、侵袭转移、血管生成与肿瘤细胞耐药中发挥重要作用。Twist能通过多种途径引起肿瘤的发生，目前已在多种人类上皮来源肿瘤中发现Twist表达增高，并与患者预后关系密切。 Twist is the important member of highly conservative basic helix-ring-spiral transcription factors family, and plays a key role on regulation of embryogenesis. The transcription factor Twist, a master regulator of embryonic morphogenesis, plays an essential role in cell motility and organization modeling. Recent studies have shown that Twist played a key role in the epithelial-mesenchymal transition, and Twist overex- pression is able to played crucial roles in tumorigenesis,invasion and metastasis, angiogenesis and drug resistance. Twist can cause cancer by many ways. At present, Twist has been found increase expression in a variety of sources of human epithelial tumors, and closely related to the prognosis of patients.
作者 肖雄升 李有柱
机构地区 广东医学院附属医院胃肠外科
出处 《医学综述》 2009年第7期1031-1034,共4页 Medical Recapitulate
关键词 TWIST 基因 表皮-间叶细胞转换 肿瘤 Twist Gene Epithelial-mesenchymal transition Tumor
分类号 R737.9 [医药卫生—肿瘤]
  • 相关文献

参考文献21

  • 1Desprez PY, Sumida T, Coppe JP. Helix-loop-helix proteins in mammary gland development and breast cancer [ J ]. Mammary Gland Biol Neoplasia ,2003,8 (2) :225-239.
  • 2Stasinopoulos IA, Mironichik Y, Raman A, et al. HOXAS-Twist interaction alters p53 homeostasis in breast cancer cells [ J ]. Biol Chem,2005,280(3 ) :2294-2299.
  • 3Stasinopoulos IA, Mironchik Y, Raman A, et al. HOXAS-Twist interaction alters p53 homeostasis in breast cancer cells [ J ]. Biol Chem,2005,280(3 ) :2294-2299.
  • 4Guenou H, Kaabeche K, Dufour C, et al. Down-regulation of ubiquitin ligase Cbl induced by twist haploinsufficiency in Saethre- Chotzen syndrome results in increased PI3K/Akt signaling and osteoblast proliferation [ J ]. Am J Pathol,2006,169 (4) : 1303-1311.
  • 5Yang J, Mani SA, Donaher JL, et al. Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis [ J ]. Cell ,2004,117 ( 7 ) :927 -939.
  • 6Castanon I, Baylies MK. A Twist in fate:evolutionary comparison of Twist structure and function [ J ]. Gene, 2002,287 ( 1/2 ) : 11-22.
  • 7Cai J, Goodman BK, Patel AS, et al. Increased risk for developmental delay in Saethre-Chotzen syndrome associated with Twist deletions:an improved strategy for Twist mutation screening [ J ]. Hum Gen,2003,114( 1 ) :68-76.
  • 8Soo K,O'Rourke MP,Khoo PL,et al. Twist function is required for the morphogenesis of the cephalic neural tube and the differentiation of the cranial neural crest ceils in the mouse embryo [ J ]. Dev Biol,2002,247 (2) :251-270.
  • 9Yuen HF, Chua CW, Chan YP, et al. Twist and E-cadherin in prostale cancer metastasis in the process of meaning[ J]. Histopathology,2007,50(5 ) :648-658.
  • 10Elias MC,Tozer KR,Silber JR,et al. Twist is expressed in human gliomas and promotes invasion[J]. Neoplasia,2005,7(9) :824-837.

二级参考文献37

  • 1王其,陈孝平,张万广,张必翔.人肝癌HepG2多药耐药细胞系的部分生物学性状研究[J].中华实验外科杂志,2004,21(5):538-540. 被引量：40
  • 2Jing Yang,Sendurai A,Mani,Joana Liu Donaher,et al.Twist,a Master Regulkator of Morphogenesis,Plays an Essential Role in Tumor Metastasis[J].Cell,2004,117:927-939.
  • 3Castanon I,Baylies MK.A Twist in fate:evolutionary comparison of Twist structure and function[J].Gene,2002,287:11-22.
  • 4Hay ED.An overview of epithelio-mesenchymal transformation[J].Acta Anat.(Basel),1995.154:8-20.
  • 5Thiery JP.Epithelial-mesenchymal transitions in tumour progression[J].Nat Rev Cancer,2002,2:442-454.
  • 6Erika Rosivatz,Ingrid Becker,katija Specht,et al.Differential Expression of the Epit helial-Mesenchymal Transition Regulators Snail,SIP1,and Twist in Gastric Cancer[J].Am J Pathol,2002,161:1881-1891.
  • 7Zorzos HS,Lazaris AC,Korkolopoulour PA.Multidrug resistance proteins and topoisomerase Ⅱ alpha expression in colon cancer:association with metastatic potential[J].Pathology,2003,Aug,35(4):315-8
  • 8Ghouzzi V, Le M, Perrin F, et al. Mutations of the TWIST gene in the Saethre-Chotzen syndrome [J]. Nat Genet, 1997, 15(1) :42-46.
  • 9Maestro R, Dei A P, Hamamori Y, et al. Twist is a potential oncogene that inhibits apoptosis [J]. Genes Dev, 1999, 13(17) :2207-2217.
  • 10Villavicencio E H, Yoon J W, Frank D J, et al. Cooperative E-box regulation of human GLI1 by TWIST and USF [J]. Genesis,2002, 32(4), 247-258.

共引文献32

同被引文献96

  • 1李丽,赵彩彦.过氧化物酶体增殖物激活受体、瘦素与非酒精性脂肪性肝病[J].国外医学（内科学分册）,2005,32(3):100-102. 被引量：1
  • 2王青青,武静,王胜杰.P14ARF在恶性肿瘤研究中的最新进展[J].现代中西医结合杂志,2005,14(22):3025-3026. 被引量：5
  • 3罗庚求,文继舫.Twist的研究进展[J].国际病理科学与临床杂志,2006,26(5):395-397. 被引量：11
  • 4Ferlay J,Shin HR,Bray F,et al.Estimates of worldwide burden of cancer in 2008:GLOBOCAN 2008[J].Int[J] Cancer,2010,127(12):2893-2917.
  • 5Levkovitch-Verbin H,Dardik R Vander S,et al.Experimental glaucoma and optic nerve tranection induce simultaneous up regulation of proapoptotic and p rosurvival genes[J].Invest Ophthalmol Vis Sci,2006,47(6):2491-2497.
  • 6Stasiopoulos LA,Mironchik Y,Raman A,et al.HOXA52 twist interaction alters p53 homeostasis in breast cancer cells[J].J Biol Chem,2005,280 (3):2294-2299.
  • 7Mason S1,Loughran O,La Thangue NB,et al.P14 (ARF) regulate E2F activity[J].Oncogene,2002,21(27):4220-4230.
  • 8Eymin B,Karayan L,Seite P,et al.Human ARF binds E2F1 and inhibits its transcriptional activity[J].Oncogene,2001,20(9):1033-1041.
  • 9Zhao L,Samuels T,Winckler S,et al.Cyclin G1 has growth inhibitory activity linked to the ARF-Mdm2-p53 and pRb tumor suppressor pathways[J].Mol Cancer Res,2003,1(3):195-206.
  • 10Calabro V,Mansueto G,Santoro R,et al.Inhibition of p53 transcriptional activity by p14AR.F:functional and physical link between human ARFtumor suppressor and a member of the p53 family[J].Mol Cell Biol,2004,24(19):8529-8540.

引证文献7

二级引证文献18

医学综述
2009年 第7期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部