摘要
目的:观察胃肠道外营养(PN)早产儿肝胆并发症的发生率,探讨早期敏感的实验室诊断指标。方法:分析113例早产儿PN相关性胆汁淤积(PNAC)的发生情况及PNAC相关的实验室指标,并比较各项指标在PNAC组与无PNAC组间的差别。结果:PNAC的发生率为13.3%。PN后1周血清谷丙转氨酶(ALT)、碱性磷酸酶(ALP)、结合胆红素(DBIL)及总胆汁酸(TBA)两组比较无显著性差异(P>0.05);PN后2周PNAC组ALP、DBIL及TBA明显高于无PNAC组,两组比较有显著性差异(P<0.05)。结论:目前使用的PN方法仍存在着影响早产儿肝胆系统功能的情况;动态监测ALP、DBIL及TBA,有助于早期发现PNAC。
Objective:To observe the incidence of parenteral nutrition(PN) associated liver complication in premature infants,explore the early laboratory indexes of diagnosis.Methods:Incidence and laboratory data of parenteral nutrition associated cholestasis(PNAC) in 113 premature infants were analysed and compared between PNAC group and non-PNAC group.Results:Incidence of PNAC in premature infants was 13.3%.There was no significant difference in serum alanine aminotransferase(ALT),alkaline phosphatase(ALP),conjugated bilirubin(DBIL) and total bile acide(TBA) between two groups on 1 week after PN(P>0.05).ALP,DBIL and TBA of PNAC group were higher than those of non-PNAC group on 2 week after PN(P<0.05).Conclusion:PN cann affects the liver function of premature infants at present.Regular monitoring of ALP,DBIL and TBA will be helpful to discover PNAC earlier.
出处
《中国妇幼保健》
CAS
北大核心
2009年第7期915-917,共3页
Maternal and Child Health Care of China
基金
珠海市科技计划项目(珠科[2007]47号)
关键词
早产儿
胃肠道外营养
并发症
Infant,premature
Parenteral nutrition
Complication
