苯丙酮尿症荧光检测光学系统的设计

Design of Phenylketonuria Fluorescence Detection Optical System

目的:设计一套专用于新生儿苯丙酮尿症(PKU)筛查的新型荧光检测光学系统。方法:该系统选取超亮紫外发光二极管作激发光源,采用不同直径的石英光纤和玻璃光纤束构成Y型传光光路,并利用自聚焦光纤对光线进行准直,使用光电倍增管进行检测。结果:该系统具有结构简单、体积小、质量小、灵敏度高等特点。结论:该系统满足临床筛查要求,为我国苯丙酮尿症的大批量筛查提供了新的快速检测手段。

Abstract Objective To design a new type of fluorescence detection optical system for dedicated neonatal PKU screening. Methods The system selects super-luminance UVLED for excitation light source, uses different diameter quartz fiber and Y-type optical fiber which consists of glass fiber bundles, and self focusing optical fiber for collimating light and photomuhiplier tubes for testing, Results The system has many features, such as simple structure, small size and high sensitivity. Conclusion The clinic screening requirements are met by the system and a new means of rapid detection is provided for PKU screening in large quantities.[Chinese Medical Equipment Journal,2009,30（3） ： 12-13]