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妊娠糖尿病患者超敏C反应蛋白与胰岛素抵抗相关性的初步探讨 被引量:6

Investigation on correlation between serum hypersensitivity C-reactive protein and insulin resistance in patients with gestational diabetes mellitus
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摘要 目的:探讨妊娠糖尿病(GDM)患者血清超敏C反应蛋白(hs-CRP)与胰岛素抵抗(IR)的关系。方法:选择41例妊娠糖尿病孕妇(GDM组)、40例糖耐量正常(NGT)的孕妇作对照(NC组),用ELISA方法测定hs-CRP水平,同时计算稳态模式胰岛素抵抗指数(HOMA-IR)。结果:①GDM组的hs-CRP、HOMA-IR分别为(10.80±3.57)mg/L、(3.96±2.16)mg/L,NC组分别为(5.96±2.56)mg/L、(2.59±0.71)mg/L,两组比较差异有统计学意义(P<0.01);②多元线性逐步回归分析显示,HOMA-IR是影响hs-CRP最为显著的因素。结论:GDM患者的血清hs-CRP水平明显升高与IR密切相关,hs-CRP与GDM的发病有关。 Objective: To explore the correlation between serum hypersensitivity C -reactive protein (hs -CRP) and insulin resistance (IR) in patients with gestational diabetes mellitus (GDM) . Methods: The levels of hs - CRP from 41 patients with GDM ( GDM group) and 40 pregnant women with normal glucose tolerance (NC group) were detected by ELISA. Homeostasis model insulin resistance in- dex ( HOMA - IR) was applied to assess the status of IR. Results: ①The levels of hs - CRP and HOMA - IR were ( 10. 80±3.57) mg/L, (3. 96 ±2. 16) in GDM group and (5. 96 ±2. 56) rag/L, (2. 59±0. 71 ) in NC group, there was significant difference in the levels ofhs - CRP and HOMA -IR between two groups (P 〈0. 01 ) ; ②A multiple linear stepwise regression analysis indicated that HOMA -IR was the most important effect factors of hs -CRP. Conclusion: The level of hs - CRP increase in women with GDM, which is related to IR and may participate in the pathogenesis of GDM.
出处 《中国妇幼保健》 CAS 北大核心 2009年第9期1184-1185,共2页 Maternal and Child Health Care of China
基金 深圳市科技和信息局资助课题(200602037)
关键词 妊娠糖尿病 超敏C反应蛋白 胰岛素抵抗 Gestational diabetes mellitus Hypersensitive C -reactive protein Insulin resistance
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参考文献8

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二级参考文献12

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