妊娠糖尿病患者超敏C反应蛋白与胰岛素抵抗相关性的初步探讨

Investigation on correlation between serum hypersensitivity C-reactive protein and insulin resistance in patients with gestational diabetes mellitus

目的:探讨妊娠糖尿病(GDM)患者血清超敏C反应蛋白(hs-CRP)与胰岛素抵抗(IR)的关系。方法:选择41例妊娠糖尿病孕妇(GDM组)、40例糖耐量正常(NGT)的孕妇作对照(NC组),用ELISA方法测定hs-CRP水平,同时计算稳态模式胰岛素抵抗指数(HOMA-IR)。结果:①GDM组的hs-CRP、HOMA-IR分别为(10.80±3.57)mg/L、(3.96±2.16)mg/L,NC组分别为(5.96±2.56)mg/L、(2.59±0.71)mg/L,两组比较差异有统计学意义(P<0.01);②多元线性逐步回归分析显示,HOMA-IR是影响hs-CRP最为显著的因素。结论:GDM患者的血清hs-CRP水平明显升高与IR密切相关,hs-CRP与GDM的发病有关。

Objective： To explore the correlation between serum hypersensitivity C -reactive protein （hs -CRP） and insulin resistance （IR） in patients with gestational diabetes mellitus （GDM） . Methods： The levels of hs - CRP from 41 patients with GDM （ GDM group） and 40 pregnant women with normal glucose tolerance （NC group） were detected by ELISA. Homeostasis model insulin resistance in- dex （ HOMA - IR） was applied to assess the status of IR. Results： ①The levels of hs - CRP and HOMA - IR were （ 10. 80±3.57） mg/L, （3. 96 ±2. 16） in GDM group and （5. 96 ±2. 56） rag/L, （2. 59±0. 71 ） in NC group, there was significant difference in the levels ofhs - CRP and HOMA -IR between two groups （P 〈0. 01 ） ; ②A multiple linear stepwise regression analysis indicated that HOMA -IR was the most important effect factors of hs -CRP. Conclusion： The level of hs - CRP increase in women with GDM, which is related to IR and may participate in the pathogenesis of GDM.