子宫内膜异位症血清及腹腔液瘦素及其受体水平分析

Analysis on levels of leptin and it's receptor in serum and peritoneal fluid of patients with endometriosis

目的:探讨子宫内膜异位症(EMs)患者血清和腹腔液瘦素及其受体水平的变化及其在EMs发病中的作用。方法:采用ELISA的方法测定42例内异症患者和36例非内异症对照组患者血清和腹腔液中瘦素及其受体的含量,并分析其与内异症病变程度的相关性。结果:内异症组患者血清瘦素及其受体水平、体重指数与对照组间比较差异无显著性(P>0.05)。内异症组腹腔液中瘦素及其受体水平明显高于对照组(P<0.01)。内异症病变轻度及重度患者腹腔液瘦素及其受体水平均明显高于对照组;内异症患者轻度病变组与重度组比较瘦素及其受体水平明显升高(P<0.05)。结论:瘦素及其受体水平在内异症患者腹腔液中明显升高,并随病变的严重程度而降低,局部瘦素系统在内异症的发生、发展中可能发挥重要作用。

Objective： To explore the levels of leptin and it＇s receptor in serum and peritoneal fluid of patients with endometriosis and their role in the pathogenesis of endometriosis. Methods： The levels of leptin and it＇s receptor in serum and peritoneal fluid from 42 patients with endometriosis （test group） and 36 patients without endometriosis （control group） were detected by ELISA. Correlation between their levels and disease degree was analyzed. Results： There was no significant difference in the levels of leptin and it＇s receptor in serum, body mass index （BMI） between test group and control group （P 〉0. 05 ） . The levels of leptin and it＇s receptor in peritoneal fluid in test group were significantly higher than those in control group （ P 〈 0. 01 ） . The levels of leptin and it＇s receptor in patients with mild endometri- osis were significantly higher than those with severe endometriosis （ P 〈 0. 05 ） . Conclusion ： The levels of leptin and it＇s receptor in peritoneal fluid increase, and decrease with the severe degree of endometriosis. The changes of levels of leptin and it＇s receptor in peritoneal fluid may play a role in the pathogenesis of endometriosis.