54例子痫前期孕妇凝血功能测定分析

Analysis on blood coagulation function in preeclampsia women

目的:观察子痫前期孕妇与正常孕妇两者间凝血功能的差异,分析其对妊娠期高血压疾病-子痫前期临床预测的意义。方法:检测54例子痫前期孕妇(其中轻度子痫前期20例,重度子痫前期34例)的凝血酶时间(TT)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FBG),并与42例正常孕妇的凝血功能进行比较。结果:轻度子痫前期孕妇的PT值低于正常孕妇,差异有统计学意义(P<0.05),FBG值高于正常孕妇,差异有统计学意义(P<0.01);重度子痫前期孕妇的TT、PT、APTT值均明显低于正常孕妇,差异有统计学意义(P<0.05),FBG值高于正常孕妇,差异有统计学意义(P(0.01)。结论:子痫前期孕妇血液的高凝状态远远超过正常孕妇,其凝血功能系统平衡失调尤以重度子痫前期为重。

Objective： To observe the difference of blood coagulation function between normal pregnant women and those with preeclampsia, analyze its predictive ,（alue in preeclampsia. Methods： Thrombin time （ TT）, prothrombin time （ PT）, partial thromboplastin time （APTT）, fibrinogen （FBG） were detected and compared in 42 healthy pregnant women, 20 pregnant women with light preeclampsia and 34 pregnant women with severe preeclampsia. Results： PT in light preeclampsia women was shorter than that in healthy pregnant women （P 〈0.05 ） , while the level of FBG was higher than that in healthy pregnant women （P 〈0. 01 ） ; TT, PT, APTT in severe preeclampsia women were significantly shorter than those in healthy pregnant women （ P 〈 0. 05 ）, while the level of FBG was higher than that in healthy pregnant women （P 〈 0. 01 ） . Conclusion： The blood coagulation function in pregnant women with preeclampsia, especially in those with severe preeclampsia, is out of balance.