VEGF和CD44v6在食管鳞状细胞癌中的表达

The expression and its clinical significance of VEGF and CD44v6 in esophageal squamous cell carcinoma

目的探讨肿瘤转移因子血管内皮生长因子VEGF、细胞黏附分子变异型CD44v6在食管鳞癌组织中的表达及临床意义。方法采用免疫组化SP法,检测54例食管鳞癌手术标本VEGF蛋白、CD44v6蛋白的表达。结果淋巴结转移组与无淋巴结转移组相比,VEGF和CD44v6表达均增强(P<0.05);大于3年生存组与小于3年生存组相比,VEGF表达降低(P>0.05),CD44v6表达增强(P<0.05);VEGF、CD44v6表达与肿瘤浸润深度呈正相关(r值=0.375、0.362,P值均<0.05),VEGF表达与病理分级呈正相关(r值=0.349,P值<0.05)。结论VEGF、CD44v6表达增强与食管鳞癌浸润转移有一定相关性,联合检测这两项指标对判断食管癌的生物学行为及预后具有重要意义。

Objective To study the expression and its clinical significance of VEGF and CD44v6 in human esophageal squamous cell carcinoma. Methods The expressions of VEGF and CD44v6 were detected by immunohistochemical SP methods in tissue samples from 54 eases of ESCC who received surgery operation only. Results The result showed that the VEGF, CD44v6 expressions were related to primary tumor invasion, metastasis of lymphnodes, invasion depth and 3 - year survival rate. Conclusion VEGF, CD44v6 might be important biologicalmarkers in ESCC and they might be related to the biological behavior of ESCC. Examination of two proteins may be helpful to judge biological behavior and prognosis of esophageal carcinoma.