缬沙坦治疗慢性心衰室性心律失常的效果观察

The effects of Valsartan on ventricular arrhythmia in patients with chronic heart failure

目的观察短期应用缬沙坦对慢性心力衰竭(CHF)患者室性心律失常的影响。方法选择78例CHF室性心律失常患者分成缬沙坦组(41例)和常规治疗组(37例)。所有CHF患者均给予常规治疗,缬沙坦组加用缬沙坦胶囊80 mg,qd,治疗6周。治疗前后分别行动态心电图检查,测量左室射血分数(LVEF),测定血清钾浓度。结果经6周治疗后缬沙坦组与常规治疗组比较室早、室速发生率明显降低(P<0.05);缬沙坦组LVEF升高比常规治疗组更明显(P<0.05)。结论短期应用缬沙坦可能对CHF患者室性心律失常有效。

Objective To investigate the effects of short - term Valsartan on ventricular arrhythmia in patients with chronic congestive heart failure （CHF）. Methods 78 patients with CHF were randomly divided into two groups ： conventional therapy group （ n = 37） and Valsartan group （n = 41 ）. All patients with CHF were treated by conventional therapy： β -adrenoceptor antagonists, diuretics and digoxin. The Valsartan group plus Valsartan 80 mg, quaque die for six weeks. Before and after treatment, the left ventricular ejection fraction （LVEF） was measured by ultrasonic cardiography. The level of serum potassium and dynamic electrocardiogram was analyzed. Results After six weeks, the incidence of premature ventricular extrasystole and ventricular tachycardia were significantly lower in the valsartan group than those in the conventional therapy group （ P 〈 0.05 ）. This corresponded with improved LVEF in the Valsartan group （P 〈 0.05）. Conclusions Short - term Valsartan therapy can improve cardiac function and decrease the rate of ventricular arrhythmia in patients with CHF.