表皮生长因子受体和血管内皮生长因子在胃近端癌组织中的表达

Expression of epidermal growth factor receptor and vascular endothelial growth factor in proximal gastric carcinoma

目的检测表皮生长因子受体(EGFR)和血管内皮生长因子(VEGF)分别在胃贲门部和胃窦部癌组织中的表达情况,了解胃贲门癌和胃窦癌的生物学特性及不良预后的原因,指导胃癌术后的治疗。方法选取手术切除的胃贲门癌组织标本64例和胃窦癌组织标本67例,常规病理检查,应用链霉菌亲生物素蛋白-过氧化物酶连接(S-P)免疫组化法检测癌组织中EGFR和VEGF蛋白表达,比较两组患者3年生存率。结果胃贲门癌组EGFR和VEGF蛋白表达率高于胃窦癌组(P<0.05)。胃贲门癌组患者3年生存率差于胃窦癌组(P<0.05)。结论胃贲门部癌组织中的EGFR和VEGF基因蛋白过度表达,与胃贲门部癌生物学行为差、预后不良存在着密切关系,反映了贲门癌有较高复发和转移危险,提示有加强贲门癌手术后辅助治疗的必要性。

Objective To detect the expressions of epidermal growth factor receptor （EGFR） and vascular endothelial growth factor （VEGF） in gastric carcinomas and to investigate the biological features and prognostic factors of antral and cardiac gastric carcinomas. Methods All patients were divided into cardiac carcinoma group （n=64） and antral carcinoma group （n=67）. The expressions of VEGF and EGFR were detected by streptavidin-peroxidase immunohistochemistry. All data were statistically analyzed. Results When compared with antral carcinoma group, VEGF and EGFR were significantly increased in cardiac gastric carcinoma group （P 〈0.05）. The survival rate was significantly lower in cardiac gastric carcinoma group than in antral gastric carcinoma group （P 〈0.05）. Conclusion Over-expressions of VEGF and EGFR in cardiac gastric carcinoma may closely connect with its higher risks of recurrence and metastasis.