TGF-β1在上皮性卵巢癌间质和上皮中的差异表达及与铂类耐药的相关性分析

The expression of transforming growth factor-β1 in the epithelium and interstitium of epithelial ovarian neoplasms and the relevance with platinum resistance

目的:检测上皮性卵巢癌间质及上皮中TGF-β1表达情况,探讨其与肿瘤铂类耐药的相关性。方法:采用免疫组织化学方法检测43例术后应用铂类药物化疗的上皮性卵巢癌标本间质和上皮中TGF-β1的表达水平,并追踪调查12个月,记录肿瘤复发情况。结果:①上皮性卵巢癌中TGF-β1在上皮中表达阳性率为58.1%,间质中为81.4%,具有显著性差异(P=0.028)。②12个月内复发组和未复发组中卵巢癌上皮内TGF-β1的阳性表达率无显著性差异(P=0.594);复发组卵巢癌间质中TGF-β1阳性表达显著高于未复发组(P=0.042)。结论:上皮性卵巢癌间质中TGF-β1表达可能提示该患者对铂类药物具有更高的耐药性。

Objective： To detect the expression of transforming growth factor - β1 （TGF - β1 ） in the epithelium and interstitium of epithelial ovarian neoplasms, approach its relevance with platinum resistance. Methods ： 43 patients treated with platinum after operations were selected. TGF - β1 expression was detected by immunohistochemistry in epithelium and interstitium of ovarian carcinoma. Results： ① The positive rate of TGF- β1 was 58. 1% in the epithelium, which was significant lower than that in the interstitium （81.4%） （P = 0. 036） . ②The expression of TGF- β1 in the epithelium which recurred in 12 months had no significant difference with the group which did not recur （ P = 0. 594） . The expression of TGF - β1 in interstitium was higher in the recurred group than that in the un - recurred group （P = 0. 042） . Conclusion： High expression of TGF- β1 in the interstitium of ovarian epithelial neoplasms may suggest higher resistance to platinum.