达英-35治疗多囊卵巢综合征的短期疗效观察

Short-term effects of Diane-35 on polycystic ovary syndrome

目的:探讨达英-35(diane-35,每片含醋酸环丙孕酮CAP2mg和乙炔雌二醇EE35mg)对多囊卵巢综合征(PCOS)患者短期治疗效果。方法:选择40例1年内暂无生育要求的多囊卵巢综合征患者,随机分为两组,即A组:达英-35治疗3个周期,B组:达英-35治疗6个周期,每组各20例,治疗前、治疗结束时及停药后3个月分别测定性激素6项,观察月经恢复情况及用药期间的副反应。结果:治疗3个周期后所有患者月经周期规律,停药后多可维持1个月,黄体生成素及睾酮下降明显,差异有显著性,P<0.05;治疗6个周期后,黄体生成素及睾酮下降更明显,P<0.01,其临床典型的内分泌症状明显改善,规律月经周期可维持2～3个月。结论:达英-35短期内治疗多囊卵巢综合征有良好的疗效,对于1年内暂无生育要求的患者,6个周期疗效优于3个周期。

Objective： To investigate the short -term effects of Diane- 35 on polycystic ovary syndrome （PCOS） . Methods： 40 non - bear within one year PCOS women were enrolled into study. They were divided into two groups randomly ： group A was given Diane - 35 for 3 cycles ： group B was given Diane - 35 for 6 cycles, their sex hormones in pretreatment, at the end of treatment and drug withdrawal 3 month were detected, at same time, their menstruation and adverse reaction were observed. Results： All women had menstrual cycle after 3 treatment cycles with Diane - 35, and can kept one cycle after withdrawal. The levels of LH and T after withdrawal were lower than those in pre- treatment （P 〈 0. 05 ）, after 6 treatment cycles, the levels of LH and T were significantly lower than those in pretreatment （P 〈 0. 01 ） . The endo- crine symptoms improved obviously, and menstrual cycle could keep 2 - 3 months. Conclusion： The short - term effect for women with poly- cystic ovary syndrome by Diane - 35 is good. Six cycles is better than three cycles in Diane - 35 treatment for PCOS non - bear within one year.