产前超声表现与染色体异常相关分析

Correlation analysis on antenatal ultrasound and chromosome abnormalities

目的:探讨产前超声表现与胎儿染色体异常的相关关系及产前超声检出胎儿染色体异常的可能性。方法:对2002年1月～2006年12月在我院行产前诊断的1388例孕妇资料及最终染色体异常的102例胎儿的产前超声筛查资料及染色体核型进行分析。结果:超声筛查染色体异常灵敏度为69.61%、特异度为78.38%,超声筛查阳性者其染色体异常发生率比超声筛查阴性者高,P<0.005。染色体异常特别是数目异常在产前超声筛查中几乎都能找到某些超声特征或微小变化。结论:染色体异常特别是数目异常在产前超声筛查有特定的声像表现规律,产前超声检查是筛查胎儿染色体异常的重要手段之一。

Objective： To explore the relationship between sonographic features and chromosomal abnormalities, find out the ability of antenatal ultrasound in the screening of chromosome abnormalities fetuses. Methods： From January 2002 to December 2006, data about 1 388 pregnant women and 102 fetuses with chromosome abnormalities were analyzed. Results： The sensitivity and specificity of sonographic detection in chromosome abnormalities fetuses were 69.61% and 78.38% , respctarily. The rate of chromosome abnormalities in fetuses with positive ultrasound finding was higher than that in fetuses with negative ultrasound finding （ P 〈 0. 005 ） . Sonographic features could be found in chromosomal abnormalities fetuses. Conclusion： Chromosome abnormalities have remarkable sonographic signs. Antenatal ultra-sound screening plays an important role in prenatal diagnosis of chromosomal abnormalities.