基质金属蛋白酶抑制剂RECK在子宫内膜异位症中的表达及临床意义

The expression and clinical significance of matrix metalloproteinase inhibitor-RECK in endometriosis

目的:研究基质金属蛋白酶抑制剂RECK及基质金属蛋白酶-2(MMP-2)、基质金属蛋白酶-9(MMP-9)在子宫内膜异位症(EMs)中的表达,探讨其在EMs发生发展中的作用。方法:应用免疫组化法检测48例异位内膜组织标本,31例正常内膜中MMP-2、MMP-9、RECK蛋白的表达情况。结果:MMP-2、MMP-9、RECK在异位内膜中的阳性表达率分别为89.6%、79.2%、43.8%,在正常内膜中阳性表达率为35.5%、19.4%、87.1%,MMP-2、MMP-9在异位内膜中表达明显高于正常内膜,RECK在异位内膜中表达明显低于正常对照组,差异有显著性(P<0.05);RECK表达与MMP-2、MMP-9表达呈负相关(r=-0.468、-0.320,P<0.05);MMP-2、MMP-9、RECK的表达与临床分期无明显相关性(P>0.05)。结论:RECK蛋白表达异常与MMP-2、MMP-9相关,在EMs发生发展中起重要作用。

Objective： To investigate the expression and clinical significance of MMP -2, MMP -9 and RECK in endometriosis. Methods： The expression of MMP -2, MMP -9 and RECK in the ectopic endometrium from 48 patients with endometriosis and the eutopic endometrium from 31 patients without endometriosis were detected. Results： The positive expression rates of MMP -2, MMP - 9 and RECK were 89.6%, 79. 2% and 43.8% in the ectopic endometrium, while the rates were 35.5%, 19.4%, 87.1% in the eutopic endometrium, there was significantly difference between eetopic endometrium and eutopic endometrium （ P 〈 0.05 ） ; the expression of RECK was negatively related to MMP - 2, MMP-9 （T=-0. 468, T = - 0. 320, P 〈 0. 05） ; the expression of RECK expression had no correlation with clinical stages （P 〉 0. 05） . Conclusion： The imbalanced expression of MMP - 2/RECK, MMP-2 and RECK may play an im- portant role in the course of the occurrence and development in endometriosis.