超声联合胎儿纤维连接蛋白的早产预测

Prediction of premature delivery by ultrasonography and fetal fibrin detection

目的:通过100例早产病例分析,研究超声联合胎儿纤维连接蛋白(fFN)预测早产的意义。方法:于孕期利用宫颈超声检测,进行早产预测;孕中晚期(22～35)周利用美国ADEZA公司生产的fFN测定试剂盒,用酶联免疫吸附(ELISA)法对100例有先兆早产征、早产史及多胎孕妇进行测定。追踪病例结果进行分析。结果:100例病例中进行超声宫颈检测其中宫颈机能不全38例,早产实际发生15例(39.5%),其中9例经环扎处理,早产实际发生2例(22.2%)。fFN测定,测试结果阳性36例,其中早产实际发生31例(86.1%)。二者联合后阳性早产发生率是92.9%,有显著提高。结论:超声宫颈检测预测早产后,进行宫颈环扎可有效降低早产发生率;宫颈检测与fFN检测两者结合可提高早产预测的准确性,并有利于及时制定有效临床治疗方案。

Objective： To explore the significance of uhrasonography and fetal fibrin detection in predicting premature delivery. Methods： Fetal fibrin kit and ELISA were used to detect 100 pregnant women with premature delivery sign, premature delivery history and polyembryony during 22 - 35 gestational weeks. Results ： Cervical incompetence and premature delivery were found in 38 and 15 women by uhrasonography, respectively 2 （22. 2% ） women were found premature delivery in 9 women undergoing cerclage Fetal fibrin detection was positive in 36 women, 31 women were found premature delivery Incidence of premature delivery was 92.9% by combined applieation of uhrasonography and fetal fibrin detection. Conclusion： Cerclage can reduce incidence of premature delivery detected by uhrasonography Ultrasonography and fetal fibrin test could improve accuracy of predicting premature delivery, in order to work out a effective treatment for premature delivery.