清热解毒软胶囊抑菌抗炎作用实验研究

Experimental Study on Bacteriostasis and Anti-inflammatory Effects of QingRenJeDuJiaoNang

目的研究清热解毒软胶囊的抑菌、抗炎作用。方法呼吸道常见致病菌用肉汤稀释法测定清热解毒软胶囊最低抑菌浓度(M IC);用蛋清诱发大鼠足肿胀、二甲苯诱发小鼠耳肿胀等急性炎症模型和大鼠棉球肉芽肿慢性炎症模型研究抗炎作用。结果清热解毒软胶囊具有体外抗菌作用,对引起呼吸道感染的9种常见病原菌和致病菌均有不同程度的抑制作用;清热解毒软胶囊具有抗炎作用,对二甲苯致小鼠耳廓肿胀、大鼠蛋清性足肿胀及大鼠棉球肉芽肿均有不同程度的抑制作用。结论本研究结果提示清热解毒软胶囊具有抑菌、抗炎作用,为清热解毒软胶囊临床用于治疗流感、上呼吸道感染、咽喉肿痛等症提供了实验参考依据。

Objective To observe the bacteriostasis and anti - inflammatory effect as of QingReJeDuJiaoNang. Methods The test checkerboard dilution was used to examine the MIC of 9 kinds of common bacteria. The anti - inflammatory effect was observed by auricular edema model induced by dimethylbenzene in mice, granulation induced by cotton ball in rats, metatarsus swelling model induced by egg white in rats. Results QingReJeDuJiaoNang had bacteriostasis effect to 9 kinds of familiar bacteria causing respiratory system infection. Furthermore, QingReJeDuJiaoNang significantly inhibited auricular edema induced by dimcthylbenzene in mice, granulation induced by cotton ball in rats, and metatarsus swelling induced by egg white in rats. Conclusion QingReJeDuJiaoNang had bacteriostasis and anti - inflammatory effect.