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肝硬化患者细菌DNA移位及临床意义

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摘要 细菌移位，即细菌或细菌产物（如细菌DNA、内毒素）从肠腔移位到肠系膜淋巴结或其他肠外组织和部位，反映宿主和微生物平衡的破坏，导致一种自我保护的炎性反应，最终引起感染。细菌移位已成为肝硬化自发感染以及高动力循环状态的主要发病机制，门脉高压形成的关键因素，并在腹水和肝肾综合征的发生发展中起重要作用。细菌移位经典的诊断标准要求肠系膜淋巴结细菌培养阳性，但获取肠系膜淋巴结需外科侵入性操作，且培养阳性率不高，使细菌移位的临床研究受到限制。新近研究建议，
作者 王孝勤 白雪帆 连建奇
机构地区 第四军医大学唐都医院感染科
出处 《中华传染病杂志》 CAS CSCD 北大核心 2009年第2期124-126,共3页 Chinese Journal of Infectious Diseases
关键词 细菌DNA 细菌移位 肝硬化患者 临床意义 肠系膜淋巴结 高动力循环状态 细菌培养 肝肾综合征
分类号 R575.2 [医药卫生—消化系统]
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参考文献13

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二级参考文献19

  • 1袁春,叶进,黄长形,连建奇.聚合酶链反应检测肝硬化患者腹水中细菌DNA[J].中西医结合肝病杂志,2005,15(2):100-102. 被引量：6
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中华传染病杂志
2009年 第2期

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