银屑病皮损组织中HSP60,HSP90与IL-2,IL-6的检测分析

Detectiam and Analysis of HSP60,HSP90 and IL-2,IL-6 in the Skin Lesion with Psoriasis

目的探索银屑病皮损组织中热休克蛋白60(HSP60)、热休克蛋白90(HSP90)与IL-2和IL-6的相关性。方法采用免疫组化法检测银屑病患者皮损组织中HSP60,HSP90,IL-2和IL-6的表达,并进行相关性分析。结果银屑病皮损组织中HSP60,HSP90,IL-2和IL-6均有明显表达;HSP60与IL-2相关系数r=0.44715,P=0.1951,HSP60与IL-6相关系数r=0.70999,P=0.0214,HSP90与IL-2相关系数r=0.52172,P=0.1219,HSP90与IL-6相关系数r=0.72386,P=0.0175。结论银屑病皮损组织中HSP60,HSP90与IL-6的表达有明显的正相关性,与IL-2的表达无相关性,HSP60和HSP90可能在银屑病发病和病程演变中起一定作用。

Objective To probe the relativity of HSP60, HSP90 and IL-2, IL-6 in the skin lesion with psoriasis. Method To detect the expression of HSP60, HSP90, IL-2 and IL-6 in the skin lesion with psoriasis by immunohistochemical way, and analyse the relativity of HSP60 and IL-2, HSP60 and IL 6, HSP90 and IL-2, HSP90 and IL-6. Results The expression of HSP60, HSP90 ,IL-2 and IL-6 in the skin lesion with psoriasis was distinct. The correlative coefficient of HSP60 and IL-2 r =0. 44715, P = 0. 1951. The correlative coeffient of HSP60 and IL-6 r = 0. 70999, P = 0. 0214 ; The correlative coefficient of HSP90 and IL-2 r = 0. 52172, P = 0. 1219, The correlative coefficient of HSP90 and IL-6 r = 0. 72386,P = 0. 0175. Conclusion The expression of HSP60, HSP90 and IL-6 in the skin lesion with psoriasis had distinct relativity, but had not distinct relativity with IL-2. HSP60 and HSP90 may play a certain function in the incidence and course of psoriasis.