多囊卵巢综合征患者CRP、hsCRP的变化与心血管疾病的相关性分析

Analysis on the correlation of cardiovascular diseases and C-reactive protein,hypersensitive C-reactive protein levels in patients with polycystic ovary syndrome

目的:研究多囊卵巢综合征(PCOS)患者C-反应蛋白(CRP)、超敏C-反应蛋白(hsCRP)的变化与肥胖、胰岛素抵抗和高雄激素血症的关系,探讨多囊卵巢综合征患者易患心血管疾病的危险因素。方法:64例PCOS和年龄、体重匹配的20例同期就诊的输卵管性不孕患者进行体重指数(BMI)、葡萄糖耐量试验(OGTT)、血清胰岛素(INS)、C-反应蛋白(CRP)、超敏C-反应蛋白(hsCRP)、血清睾酮(T)的测定,比较CRP、hsCRP在不同代谢特点的PCOS患者中和对照组中的变化。结果:PCOS组与对照组相比,CRP、hsCRP差异无显著性;PCOS中肥胖组与非肥胖组比较,CRP、hsCRP差异无显著性;PCOS中胰岛素抵抗组与非胰岛素抵抗组比较,CRP、hsCRP差异无显著性;PCOS中高睾酮组与正常睾酮组CRP、hsCRP差异有显著性(P<0.05)。结论:伴有高雄激素血症的PCOS患者远期心血管疾病的发生率可能较高。

Objective： To study the relationship between C - reactive protein （CRP）, hypersensitive C - reactive protein （hsCRP） levels and obesity, insulin resistance, hyperandrogenism in patients with polycystic ovary syndrome （PCOS）, investigate the high risk factors of cardiovascular disease in PCOS patients. Methods： The values of the BMI, OGTT and the levels of serum INS, CRP, hsCRP and androgen were tested and compared in 64 PCOS patients, 20 cases diagnosed as infertility because of oviduct factor. Results： There was no significant difference in CRP and hsCRP levels between PCOS patients and control group. There was no significant difference in CRP and hsCRP levels between obese and non - obese PCOS patients. There was no significant difference in CRP and hsCRP levels between insulin resistance and non - insulin resistance PCOS patients. There was significant difference in levels of CRP and hsCRP between PCOS patients with elevated level of serum androgen and PCOS patients with nomal level of serum androgen （P 〈 0.05 ） . Conclusion： The PCOS patients with elevated level of serum androgen may have a higher incidence of cardiovascular disease in the future.