吸入不同浓度的七氟烷对维库溴铵肌松效应的影响

Effect of sevoflurane of different concentrations on vecuronium muscle relaxation

目的:探讨吸入不同浓度的七氟烷对维库溴铵肌松效应的影响。方法:80例择期开腹手术患者随机分为4组:对照组(Ⅰ组),吸入七氟烷1MAC(Ⅱ组),1.5MAC(Ⅲ组),2MAC(Ⅳ组)。比较不同MAC七氟烷对维库溴铵肌松效应的影响。分别记录各组注入维库溴铵后其抑制时间、T1恢复时间及恢复指数。结果:起效时间Ⅱ组与Ⅰ组相比较差异无统计学意义(P>0.05),而Ⅲ组和Ⅳ组与Ⅰ组相比明显缩短(P<0.05);T125%(注药结束到T1恢复到25%)、及Tl75%恢复时间及恢复指数上,Ⅲ组和Ⅳ组与Ⅰ组相比均有明显的延长(P<0.05)。结论:吸入1.5MAC以上七氟烷明显增强维库溴铵的肌松效应。

Objective： Approach effect of sevoflurane of different concentrations on veeuronium muscle relaxation. Methods： Eighty patients scheduled for abdorminal surgery were divided randomly into four groups： comparison group （group 1）,inhalating sevoflurane with 1 MAC（group 2）, 1.5 MAC（group 3） or 2 MAC（group 4）. The effect of sevoflurane with different MAC on vecuronium muscle relaxation were observed. Inhibiting time, T1 recovery time and recovery index in four groups after vecuronium injection were recorded. Results： There was no significant difference in inhibiting time between group 1 and group 2（P〉0.05） ,and that in group 3 or group 4 was obviously shorter than in group 1 （P〈0.05）. The number of T1 25%, T1 75% and recovery index in gourp 3 and gourp 4 was notably bigger than that in group 1 （P〈0.05）. Conclusion ： Inhalating over 1.5 MAC sevoflurane strengthens vecuronium muscle relaxation and prolongs its effecting time.