雷公藤联合中等量激素治疗紫癜性肾炎的观察

Combined Application of Common Threewingnut Root and Hormone in the Treatment of Henoch-Schonlein Purpura Nephritis

目的观察雷公藤多甙(TW)联合中等量激素治疗紫癜性肾炎(HSPN)的疗效。方法2000年2月～2008年5月门诊及住院的成人HSPN共72例,随机分为治疗组36例,予TW20mg,日3次口服,联合强的松40mg,日1次口服。对照组予强的松60mg,日1次口服。观察治疗后两组尿RBC、尿蛋白定量、血浆白蛋白、肾功能、外周血IL-6的变化。结果治疗组尿RBC数量、尿蛋白和外周血IL-6含量、明显低于对照组(p<0.01),肾功能和血浆白蛋白高于对照组(p<0.05);治疗组有效率97%,完全缓解率50%,明显优于对照组的89%和26%。结论雷公藤联合中等量激素治疗紫癜性肾炎有较好的疗效。

Objective To observe the effect of the combined application of common threewingnut root （TW） and hormone on Henoch-Schonlein purpura nephritis （HSPN）. Method 72 adult patients with HSPN from the February 2000 to May 2008 were divided into common threewingnut root （TW） and hormone（TWH） group （TW 20mg orally, three times per day, combined with prednisone 40mg orally, once per day） and hormone group（prednisone 60rag orally, once per day）. The number of RBC in urine, content of urine protein and IL-6 in peripheral blood, renal function were detemined. Results The number of RBC in urine, content of urine protein and IL-6 in peripheral blood were lower in TWH group than in hormone group（p 〈 0.01）, but the renal function and content of plasma-albumin were higher in TWH than in hormone（p 〈 0.05）. The effective rate was 97% in TWH and 89% in hormone, and the complete remission rate was 50% in TWH and 26% in hormone. Conclusion Combined application of common threewingnut root and hormone is more effective than hormone in the treatment of Henoch-Schonlein purpura nephritis.