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吸入烟曲霉孢子对支气管哮喘大鼠气道黏蛋白MUC2表达的影响 被引量：1

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摘要 气道黏液过度分泌是支气管哮喘（简称哮喘）加重和死亡的危险因素。MUC2是由杯状细胞分泌的不溶性黏蛋白，哮喘患者MUC2表达上调，呼吸道黏液黏稠度和黏滞性增加，更易导致气道阻塞。流行病学资料显示烟曲霉（Aspergillus fumigatus）暴露与哮喘病情加重密切相关。我们用卵清白蛋白（ovalbumin，OVA）致敏和激发的方法建立大鼠慢性哮喘模型，然后给予长期的烟曲霉孢子吸入，观察对黏蛋白MUC2表达的影响，探讨烟曲霉暴露加重哮喘的机制。
作者 高福生 金先桥 乔建瓯 张轶
机构地区 上海交通大学附属第一人民医院呼吸科
出处 《中华结核和呼吸杂志》 CAS CSCD 北大核心 2009年第3期215-217,共3页 Chinese Journal of Tuberculosis and Respiratory Diseases
关键词 支气管哮喘 烟曲霉孢子 气道黏蛋白 MUC2 大鼠 流行病学资料 细胞分泌 呼吸道黏液
分类号 R686 [医药卫生—骨科学]
  • 相关文献

参考文献10

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二级参考文献13

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共引文献15

同被引文献17

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  • 6Denning DW, O' Driscoll BR, Hogaboam CM, et al. The link between fungi and severe asthma : a summary of the evidence. Eur Respir J, 2006, 27:615-626.
  • 7Dales RE, Cakmak S, Judek S, et al. The role of fungal spores in thunderstorm asthma. Chest, 2003, 123 : 745-750.
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  • 10Denis O, van den Brule S, Heymans J, et al. Chronic intranasal administration of mould spores or extracts to unsensitized mice leads to lung allergic inflammation, hyper-reactivity and remodeling. Immunology, 2007, 122:268-278.

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二级引证文献8

中华结核和呼吸杂志
2009年 第3期

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