微波固化治疗SD大鼠颌下腺鳞癌的疗效分析

Analysis of microwave coagulation therapy for submandibular gland squamous carcinoma of SD-rats

目的利用微波固化治疗SD大鼠颌下腺鳞癌,观察其对肿瘤的治疗效果。方法利用SD大鼠通过颌下腺分次注射4%二甲基苯丙蒽(DMBA)的药物诱癌方法建立鳞癌动物模型,筛选荷瘤大鼠为研究对象分组;将微波功率分别设定为30、40、60W,作用时间分别为3、5、6min,通过微波固化方式对肿瘤进行治疗,观察不同组合方式对组织凝固范围、肿瘤变化过程及动物生存时间等的影响。结果微波固化后见一界限清晰的以微波天线为中心的椭圆形凝固坏死区域,术后肿瘤的生长受到明显的抑制,各治疗组与对照组比较,大鼠的带瘤生存时间有显著差异(P<0.05),均明显延长。结论微波固化治疗SD大鼠颌下腺鳞癌有效,增大微波功率和延长辐射时间能够提高凝固范围。

Objective To study the effects of microwave tissue coagulation （MTC） and investigate the effects of MTC in treatment of submandibular gland squamous carcinoma. Methods 4% DMBA acetone solution was injected into the submandibular gland for inducing the animal model of squamous carcinoma to select animal model as the research objects. The antenna of microwave was put into the submandibular gland tumor and the power out-put was 30 W, 40 W and 60 W, respectively, with the working time of 3 min, 5 min and 6 min. The lesion size of microwave coagulation was measured and the specimens of coagulation tissues were observed under microscope after the experiment. Resuits An ellipse coagulation area with the axis along the antenna of the MTC was seen immediately after the therapy. The coagulated tissue was distinctively different from the surrounding normal tissues and showed the obvious anti-tumor effect. The survival time of experimental group was significantly different from that of the control group （ P 〈 0.05）. Conclusion MTC had therapeutic effects on submandibular gland squamaus carcinoma of the SD-rats. The effectiveness of coagulation could be improved through increasing the out-put power and exposure duration, but the contribution of working power to the volume of coagulation was far more than the exposure-duration.