摘要
介绍以丁二酮和丙二胺为原料合成2，3，5－三甲基吡嗪的新方法。重点考察了缩合反应温度、溶剂用量和脱氢反应时间对目标产物产率的影响，确定了合成2，3，5－三甲基吡嗪的生产工艺条件：以无水乙醇为溶剂，丁二酮、丙二胺、溶剂乙醇和DH型脱氢剂的投料配比为1：0．67：3：10（重量比），于O～－5℃缩合反应1～2h，再在溶剂回流温度下脱氢反应2～3h，2，3，5－三甲基吡嗪的收率按投料丁二酮计达59％，产品纯度≥99．0％。
A novel method for the synthesis of 2, 3, 5 - trimethylpyrazine was studied using biacetyl and propylene diamine as raw materials. The optimum conditions were established: anhydrous ethyl alco hol as the solvent, ratio of biacetyl, propylene diamine, DH - type dehydrogenated agent and solvent is 1: 0. 67: 3: 10(by weight), condensation at 0~ - 5℃ for 1~2 h, and dehydrogenation at reflux ing temperature of ethyl alcohol for 2 ~ 3 h, 2, 3, 5 - trimethylpyrazine can he obtained with 59% yields based on biacetyl, and the purity is 99. 0% or more.
出处
《精细石油化工》
CAS
CSCD
北大核心
1998年第1期19-21,共3页
Speciality Petrochemicals
