氟比洛芬酯与曲马多用于术后镇痛的临床效果比较

Analgesic Efficacy Comparison between Flurbiprofen Axetil and Tramadol in Patient Controlled Intravenous Analgesia

目的比较氟比洛芬酯与曲马多用于术后持续静脉自控镇痛(PCIA)的临床效果。方法选择全麻术后患者60例,随机分为两组,每组30例。A组:曲马多600 mg/kg+芬太尼7μg/kg+0.9%NS稀释至100 ml,B组:氟比洛芬酯150 mg+芬太尼7μg/kg+0.9%NS稀释至100 ml。两组均在术后应用PCIA,持续输注量2 ml/h,单次给药量(PCA)2 ml,锁定时间为15 min。观察术后4 h、8 h、20 h、24 h、48 h内的疼痛、镇静、恶心、呕吐评分,记录血氧、心率、呼吸频率和实际按压次数比。结果B组各时段镇痛满意度显著高于A组(P<0.05),不良反应中恶心、呕吐普遍低于A组(P<0.05)。结论氟比洛芬酯用于术后持续静脉镇痛的效果确切,不良反应发生率较曲马多显著降低。

Objective To compare the analgesic efficacy between Flurbiprofen Axetil and Tramadol in patient controlled intra- venous analgesia（PCIA）. Methods Sixty patients undergoing general anesthesia were randomly divided in two 2 groups （n = 30）. Group A administered with Tramadol 600 mg/kg ＋ Fentany 7 p,g/kg ＋0.9% NS go to 100 ml,and Group B with Flurbipro- fen Axetil 150 mg＋ Fentany 7 μg/kg ＋ 0.9% NS go to 100 ml. PCIA was performed in both groups, and each injection last 15 rain with a dosage of 2 mt/h. The pain,sedation,nausea and vomiting score were carried out on 4 h,8 h,20 h,24 h and 48 h after operation, and the blood oxygen, heart rate, respiratory frequency were recorded too. Results The satisfaction about analgesia effect in group A was better than group B （ P 〈 0.05 ） , and the incidence of adverse reaction such as nausea and vomiting in group B was lower than that of group A （ P 〈 0.05 ）. Conclusion Flurbiprofen axetil have a ideal curative effect for PCIA with a lower incidence of adverse reaction as compared with Tramadol.