摘要
本文首次报道,用从中药赤小豆(Phaseolus calcaratus Roxb)中提纯的胰蛋白酶抑制剂,剂量在400μg/0.2ml以上,在体外能全部抑制人体精子。该抑制剂对人体精子顶体粒蛋白亦有较强的抑制作用,初步探讨了它对人体精子顶体粒蛋白的抑制作用机理。通过进一步研究,赤小豆抑制荆可望成为一种新型的避孕药。
In this papar, the achievement on the trypsin inhibitor of purification from Chi-siao-dou (the seed of Phaseolus Calcaratus Roxb) has been first reportcd. It inhibits completely the spermatozoa of human body in vitro when the concentration of it is over 400μg/0.2ml, and it has stronger inhibiting effect on the acrosin of human body spermatozoa. The mechanism of inhibition effect for human body spermatozoa acrosin was also discribed. Chi-siao-dou inhibitor made it possible to become a new contraceptive drug.
出处
《福建师范大学学报(自然科学版)》
CAS
CSCD
1989年第3期76-79,共4页
Journal of Fujian Normal University:Natural Science Edition
关键词
赤小豆
胰蛋白酶
抑制剂
人体
精子
Chi-siao-dou (Phaseolus Calcaratus Roxb), acrosin, trypsin inhibitor, human body sperm