调脂积冲剂对脂肪肝大鼠胰岛素抵抗的影响

The Effect of TiaozhiJi Emulsion on Insulin Resistance of the Fatty Liver Rat

目的——探讨调脂积冲剂防治脂肪肝的有效性、可靠性,及其对胰岛素抵抗的影响。方法——采用酒精合并高脂乳剂建立大鼠脂肪肝模型,以易善复和六味地黄丸为阳性对照,检测TC、TG、HDL-C、LDL-C、ALT、GGT和FBG,采用酶联免疫法测定血清胰岛素含量。胰岛B细胞功能评价采用稳态模式评估法,即胰岛素抵抗指数(HOMA—IR)=(FBG).FINS/22.5。结果——调脂积冲剂能降低ALT、GGT、TC、TG、LDL-C、FBG和FINS的含量,降低胰岛素抵抗指数。讨论——调脂积冲剂能有效防治脂肪肝,其机制可能与其改善胰岛素抵抗有关。

Objective TiaozhiJi Emulsion of this fatty liver of the validity, reliability, and insulin resistance in the formation of fatty liver＇s role in the process. Methods Combined high - fat emulsion used alcohol fatty liver rat model toEssentiale andLiuwei- dihuangwan to as a positive control, Detected TC, TG, HDL - C, LDL - C, ALT and GGT, FBG, using enzyme - linked immunosorbent assay for determination of serum insulin levels. B islet cell function evaluation by homeostasis model assessment （HOMA） , or insulin resistance index （ HOMA - IR） = （ FBG ） · FINS/22. 5. Results The TC, TG, LDL - C, ALT and GGT, FBG, FINS, HOMA - IR, liver index were higher than those of the normal group, lower HDL - C group. TiaozhiJi Emulsion can reduce the liver index, lower ALT and GGT, TC, TG, LDL - C, FBG, FINS content, lower HOMA - IR. Conclusions TiaozhiJi Emulsion can treatment of fatty liver, improve its mechanism may be related to insulin resistance.