2型糖尿病患者高尿酸血症与下肢外周动脉病关系的临床研究

Study of relations of hyperuricemia and peripheral artery disease in type 2 diabetes patients

目的观察2型糖尿病合并高尿酸血症患者的发病情况，探讨2型糖尿病患者高尿酸血症与下肢动脉粥样硬化的关系。方法选取住院的2型糖尿病患者420例，收集相关临床资料并检测相关生化指标。采用多普勒血流探测仪专人测定糖尿病患者的足背动脉、胫后动脉与肱动脉的比值（踝肱指数），使用SPSS13．0统计软件进行数据分析和处理。结果2型糖尿病合并高尿酸血症的患者为126例。年龄、血压、尿酸水平与糖尿病患者合并外周动脉疾病有关联（P〈0．05）。尿酸是糖尿病患者发生外周动脉疾病的独立危险因素。结论高尿酸血症是糖尿病大血管并发症的危险因素，是2型糖尿病患者发生外周动脉疾病的强预报因子。

Objective To observe the incidence of hyperuricemia in type 2 diabetes patients and to explore the relations of hyperuricemia and atherosclerosis. Methods A total of 420 cases were recruited from the department of endocrinology in our study. To collect clinical data to measure biochemical indicators. The dorsal foot artery and the posterior tibial artery and the brachial artery ratio （ ankle-brachial index） were measured by professionals using the Doppler System. The data were analyzed by SPSS 13.0 software. Results The results revealed that there were 126 type 2 diabetes patients with hyperuricemia. Peripheral artery disease in patients with diabetes are relevant with age,blood pressure and uric acid （UA） （P 〈 0.05 ）. Uric acid in patients with diabetes is an independent risk factor for PAD. Conclusion Hyperuricemia is the risk factors of vascular complications in type 2 diabetes. Hyperuricemia in patients with type 2 diabetes is peripheral arterial disease-forecasting factor.