蓝斑核内注入乙酰胆碱、新斯的明及胆碱能受体阻断剂对迷走—加压反应的影响

EFFECTS OF THE LOCUS COERULEUS INJECTION OF DRUGS ON VAGUS_PRESSOR RESPONSE

采用微量注射药物的方法，研究了４７只大鼠蓝斑核内注入新斯的明、乙酰胆碱及受体阻断剂对迷走—加压反应的影响．结果表明，蓝斑（ＬＣ）内注入新斯的明及乙酰胆碱，迷走—加压反应加强；注入阿托品加压反应减弱；注入六甲双胺加压反应与注药前无明显改变．结果提示，ＬＣ参与迷走—加压反应，并且是该反应产生通路中一个重要组成部分．ＬＣ内的乙酰胆碱经Ｍ受体加强迷走—加压反应．

Forty_seven urethane anaesthetized and artificially ventilated rats are introduced in the experiment. A micro_injection of drug into the locus coeruleus is adopted to investigate the effect of acetylcholine. Neostigmine and cholinergic blocking agent on vagus_pressor response (VPR). The results are as follows: microinjection of neostigmine or acetylcholine into locus coeruleus increase the VPR value, atropine decrease the VPR value and hexamethonium has no effect on VPR value. The results indicate that locus coeruleus appears to be an important part in VPR and acetylcholine in the locus coeruleus increases VPR via cholinergic_Mreceptors.