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脓毒症中凝血酶－蛋白酶活化受体1—1－磷酸鞘氨醇信号通路的研究进展

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摘要 脓毒症是重症监护病房患者最常见的致死原因，其特征表现为促炎、抗炎和凝血反应的失控。尽管应用了新的更有效的抗生素和血管活性药物进行治疗，脓毒症的病死率仍然保持在一个很高的水平上。脓毒症造成的组织损害和器官功能障碍不仅是由于微生物的侵入，也是由于机体对感染的防御反应释放了过多的炎症介质所致。凝血系统对脓毒症中内皮细胞的炎症反应有显著的调节作用，因此，抑制凝血系统的反应可能是脓毒症治疗更有希望的方向。凝血酶是大家熟知参与凝血反应的物质之一，
作者 李岩(综述) 俞康龙(审校)
机构地区 上海交通大学附属上海市第一人民医院危重病科
出处 《中国危重病急救医学》 CAS CSCD 北大核心 2009年第3期189-191,共3页 Chinese Critical Care Medicine
关键词 凝血酶 蛋白酶活化受体1 1-磷酸鞘氨醇 脓毒症
分类号 R735.205 [医药卫生—肿瘤] R631 [医药卫生—外科学]
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参考文献23

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中国危重病急救医学
2009年 第3期

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