超微粉碎对白术中内酯成分体外溶出的影响

Effect of Ultramicronization on Dissolution of Atractylenolide from Atractylodes Macrocephala

目的:考察白术经超微粉碎后的粒度和体外溶出变化。方法:用粒度分析仪分析白术超微粉碎前后的粒径差异;以白术内酯Ⅲ、白术内酯Ⅰ含量为指标,采用高效液相色谱法测定其含量,以此反映溶出情况。结果:超微粉碎后样品粒径明显变小,约为白术细粉的30%;与白术细粉比较,白术内酯Ⅲ、白术内酯Ⅰ的含量提高约27%。结论:超微粉碎可以明显降低粒径,增加比表面积,有助于白术药材中白术内酯Ⅲ、白术内酯Ⅰ的溶出。

OBJECTIVE： To study the change in grain size and in vitro dissolution ratio of Atractylodes macrocephala after ultramicronization. METHODS： The particle size before and after ultramicronization was analyzed using particle size analyzer. The content of the sample was determined by HPLC using atractylenolide Ⅲ and atractylenolide Ⅰ as indexes to reflect the dissolution ratio. RESULTS： After ultramicronization, the particle size of the sample became thinner obviously, about 30% that of the common fine powder, and the content increased by 27% as compared with the common fine powder. CONCLUSION： The ultramicronization can significantly decrease the particle size, increase specific surface area and contribute to the dissolution of atractylenolide Ⅲ and atractylenolide Ⅰ from Atractylodes macrocephala.