摘要
目的:制备齐墩果酸滴丸并建立其质量标准。方法:按常规方法制备滴丸,采用紫外分光光度法,以齐墩果酸为对照品,在210nm波长处测定齐墩果酸含量和齐墩果酸滴丸的溶出度。结果:制得的滴丸大小均匀、圆整光滑、硬度适中。齐墩果酸的检测浓度在4～120μg.mL-1范围内与吸光度呈良好线性关系(r=0.9998);平均加样回收率为99.56%,RSD=1.15%(n=6)。齐墩果酸滴丸30min时的溶出度为(76.2±1.94)%。结论:该制备方法简单,滴丸成形性好,质量可控,体外溶出度高。
OBJECTIVE： To prepare Oleanolic acid（OA） drop pills and establish its quality standard. METHODS： The drop pills were prepared by a routine method. The content of OA and the dissolution rates of OA drop pills were determined by UV spectrophotometry under a wavelength of 210 nm taking oleanolic acid as a control. RESULTS： The drop pills were well- distributed in size, smooth and glossy in appearance, mild in hardness. The linear range for OA was 4-- 120 μg · mL^-1（r = 0.999 8） with an average recovery of 99.56% （RSD = 1.15%, n = 6） . The dissolution rate of OA drop pills at 30 min was （76.1± 1.94）%. CONCLUSION： The preparation method of OA drop pills is simple, and the drop pills are well- shaped with controllable quality and high dissolution rate.
出处
《中国药房》
CAS
CSCD
北大核心
2009年第9期666-667,共2页
China Pharmacy
关键词
齐墩果酸
滴丸
紫外分光光度法
溶出度
Oleanolic acid
Drop pills
UV spectrophotometry
Dissolution rate
