古方黄连香薷饮有效部位不同配比的药效研究

Study on pharmacodynamics of Huanglian Xingfu Decoction with different proportions of herbs

目的观察黄连香薷饮有效部位不同配比的药效。方法采用相应的动物模型,观察黄连香薷饮不同配比混合提取物的抗病毒、清热、镇痛、抗炎等作用。结果不同比例的黄连香薷饮提取物可明显抑制甲Ⅰ型流感病毒FM1株引起的小鼠肺部病变、降低肺指数,有体内抗流感病毒作用,对酵母所致发热大鼠有退热作用,对二甲苯所致小鼠耳廓肿胀有抗急性炎症的作用,有减少冰乙酸致小鼠疼痛扭体次数和提高热板致痛小鼠痛阈值的作用。结论黄连香薷饮有效部位不同配比均有一定的抗病毒、清热、镇痛、抗炎等药理作用。

Objective To study the effect of different proportions of herbs of Huanglian Xiangru Decoction on the phamaeodynamics. Methods The homologous animal models were used to observe different actions of Huanglian Xiangru Decoction with different proportions of herbs, including anti-viral, heat-clearing, analgesic, and anti-inflammatory effects. Results The extract of Huanglian Xiangru Decoction with different proportions of herbs could inhibit pathological changes in lung of mice caused by FM1 strain of Influenzavirus A and lower lung index, indicating anti-influenza activities in vivo with antifebrile effects on febrile rats caused by yeast, resistance to acute inflammation of auricular swelling of mice caused by paraxylene, decreasing writhing times of mice caused by glacial acetic acid, and increasing pain threshold of mice caused by hot plate. Conclusion Huanglian Xiangru Decoction with different proportions of herbs showed anti-viral, heat-clearing, analgesic, and anti-inflammatory effects.