期刊文献+

基于SoPC的行波介电电泳芯片控制与采集平台设计 被引量:2

Control and Acquisition Platform for Travelling Wave Dielectric Electrophoresis Chip Based on SOPC
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摘要 介绍了一种利用SoPC技术控制与采集行波介电电泳芯片的方案。以嵌入在FPGA(CyclonII EP2C35)中的RISC结构的CPU软核NiosII为基础,通过FPGA的DSP开发工具DSP Builder对直接数字频率合成器(DDS)进行建模,在QuartusII软件中生成DDS IP核,控制输出4路相位严格相差90°的正弦波,建立行波电场驱动不带电生物粒子定向移动,实现不同生物粒子的分离;采用自定制I2C模块,实现300万像素CMOS图像传感器MT9T001的配置,完成不带电生物粒子的非接触检测。文中重点介绍了基于DSP Builder的DDS IP核设计,自定制I2C模块以及系统软、硬件设计,并通过仿真分析证明了这种设计方法的正确性和实用性。 This paper presented a SOPC-based design of the control and acquisition platform for travelling wave dielectrophoresis microchip. The direct digital frequency synthesis (DDS) modeling was built using the digital signal processing (DSP) development tool of FPGA, DSP Builder. The DDS IP core was generated by Quartusll software. By the controlling of soft-core processor with RISC framework, NIOSII, which was embedded in the FPGA (Cyclonll EP2C35), the four-phase DDS module with 90 degree phase shift drive four channels AC signal outputs. The resultant travelling wave dielectrophoresis electric field drove the biologic particle without charge direction moving, to achieve biologic panicle separation in dielectrophoresis microchip. Adopting the custom I^2C module, the configuration of 3-Megapiexel CMOS active-pixel digital image sensor, MT9T001, implemented the contactless detection of the different biologic particle without charges. The design of DDS IP core based on DSP Builder, the design of custom I^2C module, the hardware framework and software design of control system were introduced. The simulation results demonstrated the feasibility of the design.
出处 《仪表技术与传感器》 CSCD 北大核心 2009年第2期100-103,共4页 Instrument Technique and Sensor
基金 国家自然科学基金项目(60571009) 湖北省教育所科学研究项目(Q20082904)
关键词 SOPC 介电电泳芯片 DDS matlab和DSP BUILDER CMOS图像传感器 SOPC dielectric electrophoresis chip DDS matlab and DSP Builder CMOS image sensor.
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参考文献11

  • 1PETHIG R. Dielectrophoresis:using inhomogeneous AC electrical fields to separate and manipulate cells. Crit. Rev. Biotechnol. 1996, 16:331 -348.
  • 2CHENG J, SHELDON E L, WU L,et al. Preparation and hybridization analysis of DNAJRNA from E-coli on microfabricated bioelectronic chips. Nature Biotechnology, 1998,16:541 - 546.
  • 3HUANG C T, CHEN A L, WANG L, et al. Electrokinetic measurements of dielectric properties of membrane for apoptotic HL-60 cells on chip-based devices. Biomedical Microdevices. Biomedical Microdevices ,2007,9:335 - 343.
  • 4ARNOLD W M,ZIMMERMANN U. Electro-rotation:development of a technique for dielectric measurements on individual cells and particles. Journal of Electrostatics,1988,21:151 - 191.
  • 5HUANG Y,HOLZEL R,PETHING R,et al. Differences in the AC electrodynamics of viable and non-viable yeast cells determined through combined dielectrophoresis and electromtation studies. Phys Med Biol. ,1992,37(7) : 1499 - 1517.
  • 6WANG X B, HUANG Y. A unified theory of dielectrophores is and traveling wave dielectrophoresis. J Phys D Appl Phys, 1994,27 ( 7 ) : 1571 - 1574.
  • 7许芬,曾建军.基于DM642的高性能CMOS图像采集系统的设计[J].北方工业大学学报,2007,19(3):21-25. 被引量:2
  • 8REINHARDT V S. Spur reduction techniques in direct digital synthesis, IEEE Prec,47 th AFCS, 1993:230 - 241.
  • 9周立功.NiosⅡ SOPC嵌入式系统开发指南.广州周立功单片机发展有限公司,2005:120-128.
  • 10廖红华.基于高分辨率面阵CCD的图像采集系统研究[EB/OL].[2006-12-07].http://202.114.9.5/kns50.

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同被引文献14

  • 1郝迎吉,张明,王洪波.多路温度采集及监控系统的设计与实现[J].国外电子元器件,2007(6):21-22. 被引量:6
  • 2HARRISON D J, FLURI K, SEILER K, et al. Micromachining a minia- turized capillary electrophoresis-based chemical analysis system on a chip. Science, 1993,261 (5123 ) :895 - 897.
  • 3DASGUPTA P K, LIU S R. Electroosmosis: A Reliable Fluid Propul- sion System for Flow Injection Analysis. Analytical Chemistry, 1994,66 ( 11 ) :1792 - 1798.
  • 4BAI H Y, LIN S L, CHUNG Y T, et al. Quantitative determination of 8- isoprostaglandin F2 in human urine using microfluidic chip-based nano-liquid chromatography with on-chip sample enrichment and tan- dem mass spectrometry. Journal of Chromatography A, 2011, 1218 (15) :2085 -2090.
  • 5LIU W, WEI H, LIN Z, et al. Rare cell chemiluminescence detection based on aptamer-specific capture in microfluidic channels. Biosensors and Bioelectronics,2011,28( 1 ) :438 -442.
  • 6ZHANG X W,ZHANG Z X. Quantification of domoic acid in shellfish samples by capillary electrophoresis-based enzyme immunoassay with electrochemical detection. Toxicon ,2012,59 (6) :626 - 632.
  • 7ZHANG X W, ZHANG Z X. Capillary electrophoresis-based immuno- assay with electrochemical detection as rapid method for determina- tion of saxitoxin and decarbamoylsaxitoxin in shellfish samples. Jour- nal of Food Composition and Analysis ,2012,28 (1) :61 -68.
  • 8ZHANG X W,ZHANG Z X. Development of a Capillary Electropho- resis - based Enzyme Immunoassay with Electrochemical Detection for the Determination of Okadaic Acid and Dinophysistoxin2 in Shellfish Samples. Analytical Letters ,2012,45 ( 11 ) : 1365 - 1376.
  • 9王晓银,王彦瑜.多路温度监测系统研制[J].核电子学与探测技术,2008,28(1):5-8. 被引量:1
  • 10廖红华,王骏,周文利,陈建军,易金桥,于军.基于SoPC的电泳芯片电导检测系统[J].仪表技术与传感器,2008(10):66-68. 被引量:4

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