垂体后叶素不同给药方法治疗肺结核咯血患者的效果观察及护理

Efficacy of different protocols of pituitrin administration on treating patients with tuberculosis accompanied by hemoptys

目的观察垂体后叶素不同给药方法治疗肺结核咯血患者的效果及总结护理要点。方法将2007年1月～2008年8月本科室收治的76例肺结核咯血患者采用配对的方法分为观察A、B两组,观察A组采用间隔静脉滴注法,观察B组采用持续法静脉滴入垂体后叶素,比较两种给药方法治疗效果。结果持续静脉滴注和间隔静脉滴注给药方法治疗总有效率分别为97.4%与68.4%,两组比较,差异具有统计学意义(P<0.001);在止血时间、垂体后叶素的副作用等方面比较,差异均有统计学意义(均P<0.001),持续静脉滴注给药法比间隔静脉滴注法止血效果好、易于维持、不良反应少。结论持续静脉滴注给药具有止血时间短、容易维持和不易发生副作用等优点,值得推广应用。静脉滴注过程中应密切观察患者的咯血情况、生命体征及不良反应等。

Objective To assess the efficacy of different protocols of pituitrin administration on treating hemoptysis, accompanied by tuberculosis. Methods Seventy-six tuberculosis patients with hemoptysis admitted to our hospital during Jan 2007 to Aug 2008 were divided into group A and group B. Pituitrin was administered to group A through intermittent intravenous drip and to group B through continuous intravenous drip. The outcomes of two protocols were compared. Results The total effective rates through continuous intravenous drip and intermittent intravenous drip was 97.4% and 68.4%, respectively, and the difference was significant （P 〈 0.05）. Significant differences were also found in the time needed to stop bleeding, the effective drug duration and the side effects （P 〈 0.05） between the two protocols, with continuous intravenous drip having better efficacy, longer duration and less adverse effects. Conclusions The protocol of continuous intravenous drip of pituitrin deserves generalizing because it stops bleeding sooner,has longer effect and makes less adverse effects. The patients should be closely monitored and carefully watched against hemoptysis and adverse effects.