肠易激综合征心理状态与去甲肾上腺素、酪氨酸羟化酶

Mental status of irritable bowel syndrome patients and norepinephrine,tyrosine hydroxylase

肠易激综合征(IBS)为7种经典心身疾病之一,精神因素在发病中占据重要地位,80%以上的IBS患者症状加重与精神因素有明显关系。去甲肾上腺素(NE)能系统与情感、行为及意识状态有关,脑内NE功能异常可导致抑郁、焦虑类疾病并在某些应激状态下表现出来或恶化,肾上腺素能交感神经失调与部分IBS发病有关。酪氨酸羟化酶(TH)作为NE合成的限速酶,与抑郁症密切相关。研究脑-肠轴各层面中NE和TH的变化趋势有助于进一步了解IBS尤其是IBS伴焦虑、抑郁状态者的发病机制。

Irritable bowel syndrome （IBS） is one of seven classic psychosomatic disorders. Mental disorders are important factors in the pathogenesis of IBS, and more than 80% IBS patients＇ increased symptoms are related with mental disorders. Norepinephrine （NE） system is concerned with affection, behavior and consciousness. The abnormal NE function in the brain can lead to depression and anxiety and so on, so disturbance of NE sympathetic nerve is relevant to IBS. Tyrosine hydroxylase （TH） , the limited enzyme in the synthesis process of NE, has much to do with depressive disorder. So the study of NE and TH in the parts of brain-gut axis can help us to understand pathogenesis of IBS especially those who are accompanied with anxious and depressive state.