还原型谷胱甘肽联合甘草酸二胺治疗肝功能损害60例分析

Glutathione combined with diammonium glycyrrhizinate treated liver function damage: an analysis of 60 cases

为了观察还原型谷胱甘肽(GSH)联合甘草酸二胺与单用甘草酸二胺治疗急性感染性疾病所致肝功能损害的临床疗效,将肝损害患者120例随机分为联合治疗组(60例)和甘草酸二胺组(60例)。疗程均为2周,对比用药前后的肝功能指标变化情况。结果显示两组患者治疗后第2周末ALT、AST、γ-GT、ALP值较治疗前显著降低,其中联合组ALT、AST值较对照组下降更明显,ALT、AST治愈率较甘草酸二胺组高(P<0.05)。GSH联合甘草酸二胺治疗急性感染性疾病所致肝功能损害近期疗效显著、安全。

To compare the therapeutic effect of diammonium glycyrrhizinate along or combination with reduced glutathione on liver function damage induced by severe acute infectious disease, one hundred and twenty cases were divided into two groups randomly： diammonium glycyrrhizinate with GSH group （60 cases） and single diammonium glycyrrhizinate treatment group （60 cases）. Data regarding the liver function of patients were analyzed after two weeks treatment. Serum ALT, AST, γ-GT and ALP levels decreased obviously in both groups after two weeks treatment. Compared with single diammonium glycyrrhizinate treatment group, the levels and cure rate of serum ALT, AST in diammonium glycyrrhizinate with GSH group had significant differences （P 〈 0. 05 ）. Diammonium glycyrrhizinate associated with reduced glutathione could more effectively control the liver function damage in patients with severe acute infectious disease.