嗜碱粒细胞与支气管哮喘发病机制的研究进展
Pwgress in basophil and the mechanism of bronchial asthma
摘要
嗜碱粒细胞是支气管哮喘（哮喘）炎症发生过程中重要的效应细胞之一，它通过IgE介导引起组胺、缓激肽等血管活性介质释放，导致支气管黏膜水肿、黏液分泌增加、平滑肌收缩、气道痉挛，引起哮喘急性发作，并可诱导气道嗜酸性细胞等炎性细胞浸润并引起气道高反应性，还可以通过促进辅助T细胞2类细胞因子的表达促进哮喘的发展，并引起主要的气道炎症，最终导致气道重建。因此，进一步的研究可为哮喘的发病机制和治疗提供新的视角和途径。
出处
《国际儿科学杂志》
2009年第2期170-172,共3页
International Journal of Pediatrics
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