α-aetinin-4与肾脏疾病研究进展
Progress in the association of α-actinin-4 and renal diseases
摘要
α-actinin-4为辅肌动蛋白家族成员之一，广泛表达于体内各种组织或器官，在肾脏主要表达于肾小球足细胞。α-actinin-4具有多种生物学功能，其不仅参与细胞迁移，并可作为信号分子参与信号传导过程。α-actinin-4的编码基因ACTH4点突变导致局灶节段性。肾小球硬化，呈家族性常染色体显性遗传。研究发现多种。肾脏疾病均存在ACTH4突变或α-actinin-4分布及表达的改变。该文就α-actinin-4的生物学功能及其与肾脏疾病的关系作一综述。
出处
《国际儿科学杂志》
2009年第2期207-209,共3页
International Journal of Pediatrics
基金
安徽省自然科学基金资助项目（050430709）
参考文献26
-
1Asanuma K, Mundel P. The role of podocytes in glomerular pathobiology. CAin Exp Nephrol,2003,7(4) :255-259.
-
2Michaud JL, Lemieux LJ, Dube M, et al. Focal and segmental glomerulosclerosis in mice with podocyte-specific expression of mutant alpha-actinin- 4.J Am Soc Nephrol,2003,14(5) : 1200-1211.
-
3Yao J, Le TC, Kos CH, et al. Alpha-actinin-4-mediated FSGS: an inherited kidney disease caused by an aggregated and rapidly degraded cytoskeletal protein. PLoS Biol, 2004,2 ( 6 ): e167.
-
4Goto H, Wakui H, Komatsuda A, et al. Renal alpha-actinin-4: purification and puromycin aminonucleoside-binding property. Nephron, 2003,93 ( 1 ) : e27-35.
-
5Kos CH, Le TC, Sinha S, et al. Mice deficient in alpha-actinin-4 have severe glomerular disease. J Clin Invest,2003,111(11) : 1683-1690.
-
6Fan Q, Xing Y, Ding J, et al. The relationship among nephtin, podocin, CD2AP,and alpha-actinin might not be a true 'interaction 'in podocyte. Kidney Int, 2006,69(7) : 1207-1215.
-
7Chen VC, Li X, Perreault H, et al. Interaction of zonula occludens- 1 (ZO- 1 ) with alpha-actinin-4: application of functional proteomics for identification of PDZ domain-associated proteins. J Proteome Res, 2006,5 (9) :2123-21M.
-
8Patrie KM, Drescher AJ, Welihinda A, et al. Interaction of two actinbinding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1 .J Biod Chem,2002,277(33):30183-30190.
-
9Dandapani SV, Sugimoto H, Matthews BD, et al. alpha-actinin--4 is required for normal podocyte adhesion. J Biol Chem, 2007,281 ( 1 ) :467--477.
-
10Nakatsuji H, Nishimura N, Yamamura R, et al. Involvement of actinin-4 in the recruitment of JRAB/MICAL-L2 to cell-cell junctions and the formation of functional tight junctions. Mol Cell Biol, 2008,28 (10) : 3324-3335.
-
1侯丽婷,王效增.多支冠脉血管多次FFR测定1例报告[J].吉林医学,2015,36(13):2784-2784.
-
2王艳秋,李德天,李岩,任青,严海东.α-actinin在阿霉素肾病大鼠蛋白尿产生中的作用[J].肾脏病与透析肾移植杂志,2004,13(2):159-160. 被引量：2
-
3施晓华,武欣生,费建,陈珏.舒芬太尼在小儿心脏手术中的应用[J].临床麻醉学杂志,2006,22(11):867-868. 被引量：1
-
4闫现花,张修振,丁秀和,王荣.糖尿病肾病患者肾小球中α-辅肌动蛋白-4和肾病蛋白的表达及其临床意义[J].临床内科杂志,2011,28(10):675-677. 被引量：4
-
5范青锋,丁洁,邢燕,管娜,张敬京.通过基因敲低探讨多个足细胞分子作用及分子间反应[J].中华肾脏病杂志,2005,21(10):43-49. 被引量：4
-
6岳玲,范荣.舒芬太尼在老年患者全麻诱导中对血液动力学的影响[J].中国实用医药,2008,3(22):121-121. 被引量：5
-
7王竹,孙万森,刘俊田,李睿萍,王晔.祛风通络方对阿霉素诱导的肾病大鼠足细胞Synaptopodin、α-Actinin-4蛋白的影响[J].山西医科大学学报,2014,45(11):1022-1027. 被引量：2
-
8许济安,张玲珍.复方氨基酸静滴致过敏反应[J].药物不良反应杂志,2002,4(2):86-86. 被引量：3
-
9叶学文,贺玲,乔永贵.舒芬太尼术后患者自控静脉镇痛的临床观察[J].现代中西医结合杂志,2009,18(35):4425-4425.
-
10王玲.舒芬太尼术后镇痛在剖宫产中的应用[J].现代中西医结合杂志,2011,20(29):3726-3726. 被引量：20
