口服避孕药在体外受精周期中的应用进展

Progress of the Application of Oral Contraceptive in IVF Cycles

目前口服避孕药(OCs)在体外受精(IVF)周期中广泛应用,但各位学者研究结果不一。多数文献认为,口服避孕药应用于卵巢高反应和低反应患者可以改善体外受精临床结局,而口服避孕药应用于卵巢正常反应患者,除在促性腺激素释放激素拮抗剂(GnRHA)周期可通过其对月经周期进行控制,有计划地安排工作以外,并不改变体外受精临床结局。口服避孕药停药后5d或月经第3天给促性腺激素(Gn)优于停药后2d给促性腺激素。选择合理的口服避孕药用药方案和临床适应症对改善体外受精临床结局起着重要作用。

At present, oral contraceptive （OC） has been widely employed in in vitro fertilization （IVF） cycles. However, the results from different researchers were inconsistent. Most of literatures showed that the application of OC can improve clinical outcomes of IVF in patients with high ovarian response and poor ovarian response, while it won＇t alter outcomes of IVF in patients with ovarian normal reaction, except for controlling menstrual cycle and scheduling work during the gonadotropin-releasing hormone antagonist （GnRHA） cycles. The administration of gonadotropin （Gn） on the 5th day after OC withdrawal or the 3rd day of menstruation was superior to the 2nd day after drug withdrawal. The selections of reasonable OC medication and clinical indications play important roles in improving the clinical outcomes of IVF.