摘要
In the post genome era, a major goal in molecular biology is to determine the function of the many thousands of genes present in the vertebrate genome. The zebrafish ( Danio redo) provides an almost ideal genetic model to identify the biological roles of these novel genes, in part because their embryos are transparent and develop rapidly, The zebrafish has many advantages over mouse for genome-wide mutagenesis studies, allowing for easier, cheaper and faster functional characterization of novel genes in the vertebrate genome. Many molecular research tools such as chemical mutagenesis, transgenesis , gene trapping, gene knockdown,
在柱子染色体时代,在分子的生物学的一个主要目标是决定在脊椎动物染色体在场的许多几千基因的功能。zebrafish (Danio rerio ) 提供一个几乎理想的基因模型识别这些新奇基因的生物角色,部分地因为他们的胚胎是透明的并且很快发展。zebrafish 为染色体宽的 mutagenesis 研究比老鼠有许多优点,允许在脊椎动物染色体的新奇基因的更容易、更便宜、更快的功能的描述。许多分子的研究工具象化学 mutagenesis 那样, transgenesis,套住的基因,基因击倒, TILLING,指向的基因, RNAi 和化学基因屏幕现在在 zebrafish 是可得到的。联合所有前面、反向、化学的基因工具, zebrafish 将做无价的贡献到脊椎动物,这被期望在基因,当模特儿的人的疾病和药发现的功能的注解的功能的 genomics。